Comparison

SR9009 European Partner

Item no. TMO-T3685-1ml
Manufacturer TargetMol
CASRN 1379686-30-2
Amount 1 mL
Quantity options 100 mg 10 mM x 1 mL (in DMSO) 10 mg 1 mg 1 mL 25 mg 2 mg 500 mg 50 mg 5 mg
Category
Type Chemicals
Specific against other
Smiles CCOC(=O)N1CCC(CN(Cc2ccc(s2)[N+]([O-])=O)Cc2ccc(Cl)cc2)C1
ECLASS 10.1 32160000
ECLASS 11.0 32160000
UNSPSC 12000000
Alias REV-ERB Agonist II, Stenabolic
Shipping Condition Cool pack
Available
Manufacturer - Targets
Autophagy
Shipping Temperature
cool pack
Storage Conditions
-20°
Molecular Weight
437, 94
Target names or alias
Stenabolic , REV-ERB Agonist II
Description
SR9009 (Stenabolic), a REV-ERB agonist, increases the constitutive repression of genes regulated by REV-ERBα/ERBβ (IC50: 670/800 nM). Through activation of REV-ERB, SR9009 can decrease circadian locomotor activity during the dark phase and alter the expression pattern of core clock genes in the hypothalami of mice. The circadian pattern of expression of an array of metabolic genes in the liver, skeletal muscle, and adipose tissue was also altered in mice exposed to SR9009, resulting in increased energy expenditure. In Diet-induced obese mice, SR9009 (100 mg/kg, i.p., b.i.d., for 30 days) could decrease fat mass and markedly improve dyslipidemia and hyperglycemia.
Pathways
Autophagy

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 1 mL
Available: In stock
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