OTS514

Item no.	TMO-T4134L-25mg
Manufacturer	TargetMol
CASRN	1338540-63-8
Amount	25 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 200 mg 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Formula	C21H20N2O2S
Smiles	C[C@@H](CN)c1ccc(cc1)-c1c(O)cc(C)c2[nH]c(=O)c3sccc3c12
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	OTS514 HCl,OTS514 Hydrochloride,OTS-514,OTS 514
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Apoptosis\|\|\|TOPK
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	364.46
Description	OTS514 (OTS514 Hydrochloride) is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell lines (IC50: 0.4 ~ 42.6 nM). Treatment with OTS514 suppressed forkhead box protein M1 (FOXM1) activity. OTS514 treatment reduced CD90-positive SCLC cells and showed a higher cytotoxic effect against lung sphere-derived CSC-like SCLC cells.
Pathways	MAPK\|\|\|Apoptosis
Bioactivity	OTS514 is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell lines (IC50: 0.4 ~ 42.6 nM). Treatment with OTS514 suppressed forkhead box protein M1 (FOXM1) a

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Amount: 25 mg

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