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ICG-001

ICG-001

Item no.	TMO-T6113-500mg
Manufacturer	TargetMol
CASRN	780757-88-2
Amount	500 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Formula	C33H32N4O4
Smiles	Oc1ccc(C[C@@H]2N3[C@H](CN(Cc4cccc5ccccc45)C2=O)N(CCC3=O)C(=O)NCc2ccccc2)cc1
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	Wnt/beta-catenin,Wnt/beta-catenin,Epigenetic Reader Domain,Apoptosis
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Epigenetic Reader Domain\|\|\|Apoptosis\|\|\|Wnt/beta-catenin
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	548.63
Description	ICG001 is a β-catenin/TCF-mediated transcription inhibitor that selectively blocks β-catenin/CBP interaction without interfering with β-catenin/p300 interaction. It specifically binds to CREB protein with an IC50 of 3 μM.
Pathways	Apoptosis\|\|\|Cytoskeletal Signaling\|\|\|Chromatin/Epigenetic\|\|\|Stem Cells
Bioactivity	ICG-001 antagonizes Wnt/Î²-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 Î¼M, but is not the related transcriptional coactivator p300.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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