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SKI-178

SKI-178

Item no.	TMO-T9014-2mg
Manufacturer	TargetMol
CASRN	1259484-97-3
Amount	2 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 200 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Smiles	COc1ccc(cc1)-c1cc([nH]n1)C(=O)N\N=C(/C)c1ccc(OC)c(OC)c1
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	S1P Receptor,Apoptosis
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Apoptosis\|\|\|S1P Receptor
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	394.42
Description	SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1.
Pathways	Apoptosis\|\|\|GPCR/G Protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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