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IRE1α kinase-IN-1

IRE1α kinase-IN-1

Item no.	TMO-T9564-5mg
Manufacturer	TargetMol
CASRN	2328097-41-0
Amount	5 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Smiles	CN1CCC(CNc2cc(Cl)nn3c(cnc23)-c2cc3nc(Nc4ccccc4)[nH]c3cc2F)CC1
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Targets	IRE1
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	504.99
Description	IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM, displaying 100-fold selectivity over the IRE1β isoform. It inhibits ER stress-induced IRE1α oligomerization and autophosphorylation, as well as IRE1α RNase activity (IC50=80 nM).
Pathways	Cell Cycle/Checkpoint

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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