CHZ868

Item no.	TMO-TQ0061-1ml
Manufacturer	TargetMol
CASRN	1895895-38-1
Amount	1 mL
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Formula	C22H19F2N5O2
Smiles	CC(=O)Nc1cc(Oc2ccc3n(C)c(Nc4ccc(F)cc4F)nc3c2C)ccn1
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	JAK,JAK,JAK,JAK
Shipping Condition	Cool pack
Available
Manufacturer - Targets	JAK
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	423.42
Description	CHZ868 is a type II JAK inhibitor with potential antitumor activity that reverses the persistence of type I JAK inhibitors and can be used to study leukemia.
Pathways	Tyrosine Kinase/Adaptors\|\|\|Chromatin/Epigenetic\|\|\|Stem Cells\|\|\|Angiogenesis\|\|\|JAK/STAT signaling
Bioactivity	CHZ868 is a type II JAK2 inhibitor (IC50: 0.17 Î¼M in EPOR JAK2 WT Ba/F3 cell).

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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