« Back
Home /
PF-06424439

PF-06424439

Item no.	DCC-DC34453-1g
Manufacturer	DCChemicals
CASRN	1469284-78-3
Amount	1 g
Quantity options	100 mg 1 g 250 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Applications	IC
Specific against	other
Purity	>98%
Smiles	ClC1C([H])=NN(C=1[H])C1(C2=NC3=C(C([H])=C([H])C(=N3)N3C([H])([H])C([H])([H])C([H])([H])[C@@]([H])(C(N4C([H])([H])C([H])([H])C([H])([H])C4([H])[H])=O)C3([H])[H])N2[H])C([H])([H])C1([H])[H]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Manufacturer - Applications	PF-06424439 is a potent and selective Diacylglycerol Acyltransferase 2 ( DGAT2) inhibitor with DGAT2 IC50 ± SEM (nM) (human/rat/dog) 14 ± 1/38 ± 4/16 ± 1. PF-06424439 demonstrated excellent ADMET properties and decreased circulating and hepatic lipids when orally administered to dyslipidemic rodent models. PF-06424439 inhibited DGAT2 of different species (human, rat, and dog) with similar potency. Among related acyltransferases, no significant inhibition was observed for PF-06424439 (up to 50 μM) against human MGAT2 or MGAT3, DGAT1, or mouse MGAT1, indicating a high selectivity (>2000-fold) against these enzymes.
Molecular Weight	439, 9411

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 1 g

available

Delivery expected until 2/26/2026

Compare

Add to wishlist

Get an offer

Request delivery time