« Back
Home /
TAS4464

TAS4464

Item no.	DCC-DC60190-250mg
Manufacturer	DCChemicals
CASRN	1848959-10-3
Amount	250 mg
Quantity options	100 mg 1 g 250 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Chemicals
Applications	ELISA, other
Specific against	other
Smiles	CCOC1=C(C#CC2C3=C(N=CN=C3N)N(C=2)[C@H]4[C@H](O)[C@H](O)[C@@H](CNS(=O)(N)=O)O4)C(F)=CC=C1
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Available
Manufacturer - Applications	TAS4464 is a highly potent and selective inhibitor of NEDD8 (IC50 of 0.955 nM). TAS4464 selectively inhibited NAE relative to the other E1s UAE and SAE. TAS4464 treatment inhibited cullin neddylation and subsequently induced the accumulation of CRL substrates such as CDT1, p27, and phosphorylated IκBα in human cancer cell lines. TAS4464 showed greater inhibitory effects than those of the known NAE inhibitor MLN4924 both in enzyme assay and in cells.
Molecular Weight	506, 5073

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 250 mg

available

Delivery expected until 7/3/2025

Express Delivery: Save 6 days

Compare

Add to wishlist

Recommend by mail