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LY-3537982

LY-3537982

Item no.	DCC-DC70578-1g
Manufacturer	DCChemicals
CASRN	2414198-64-2
Amount	1 g
Quantity options	100 mg 1 g 250 mg
Category	In Vivo Reagents & Chemicals Molecules
Type	Chemicals
Applications	other, IV
Specific against	other
Smiles	ClC1C(C2C=CC(=C3C=2C(C#N)=C(N)S3)F)=C(C=C2C=1OC[C@@]1([H])CN(C(C=C)=O)CN1C2=O)F
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Available
Manufacturer - Applications	LY-3537982 (LY3537982) is a highly selective and potent KRAS-G12C inhibitor, selectively inhibits growth of KRAS G12C mutant cells (IC50=1-60 nM).LY-3537982 does not inhibit growth of KRAS G12S/G13C/G12D mutant cells and WT KRAS cells (CI50>10 uM).LY-3537982 displays high selectivity for proteome-wide cysteine residues was evaluated using competitive chemical proteomics (8866 peptides).LY3537982 inhibits the growth of subcutaneous EL3187 NSCLC PDX tumors in nude mice in a dose dependent manner.LY3537982 demonstrates robust tumor regression in combination with other agents in KRAS G12C in vivo models.LY3537982 is a promising KRAS G12C inhibitor predicted to deliver >90% KRAS G12C target occupancy in the clinic.
Molecular Weight	500, 91

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1 g

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Delivery expected until 11/13/2025

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