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Thyrotropin

Thyrotropin

Item no.	HY-107916-100mg
Manufacturer	MedChem Express
CASRN	9002-71-5
Amount	100 mg
Quantity options	100 mg 10 ug 1 ea 5 ug
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Citations	[1]Wolf G. The regulation of the thyroid-stimulating hormone of the anterior pituitary gland by thyroid hormone and by 9-cis-retinoic acid. Nutr Rev. 2002 Nov;60(11):374-7. \|[2]Vassart G, et al. The thyrotropin receptor and the regulation of thyrocyte function and growth. Endocr Rev. 1992 Aug;13(3):596-611.\|[3]Kim SM, et al. Thyrotropin, Hyperthyroidism, and Bone Mass[J]. J Clin Endocrinol Metab. 2021 Nov 19;106(12):e4809-e4821.\|[4]Chandrasekar A, et al. Regulation of Thyroid Hormone Gatekeepers by Thyrotropin in Tanycytes[J]. Thyroid. 2024 Feb;34(2):261-273.\|[5]Ono H, et al. Involvement of thyrotropin in photoperiodic signal transduction in mice. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18238-42.\|[6]Marians RC, et al. Defining thyrotropin-dependent and -independent steps of thyroid hormone synthesis by using thyrotropin receptor-null mice. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15776-81.\|[7]Colzani RM, et al. The effect of recombinant human thyrotropin (rhTSH) on thyroid function in mice and rats. Thyroid. 1998 Sep;8(9):797-801.\|[8]van der Weerd K, van Hagen PM, Schrijver B, Heuvelmans SJ, Hofland LJ, Swagemakers SM, Bogers AJ, Dik WA, et al. Thyrotropin acts as a T-cell developmental factor in mice and humans. Thyroid. 2014 Jun;24(6):1051-61.\|[9]Denef JF, et al. The influence of thyrotropin and growth hormone on the thyroid gland in the hereditary dwarf mouse: a morphometric study. Endocrinology. 1980 Oct;107(4):1249-57.\|[10]Winand R J, et al. Thyrotropin effects on thyroid cells in culture. Effects of trypsin on the thyrotropin receptor and on thyrotropin-mediated cyclic 3': 5'-AMP changes. Journal of Biological Chemistry, 1975, 250(16): 6534-6540.\|[11]Medina DL, et al. Thyrotropin-dependent proliferation of in vitro rat thyroid cell systems. Eur J Endocrinol. 2000 Aug;143(2):161-78.\|[12]Dumont JE, et al. Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors. Physiol Rev. 1992 Jul;72(3):667-97.\|[13]Li X, et al. Thyrotropin prevents apoptosis by promoting cell adhesion and cell cycle progression in FRTL-5 cells. Endocrinology. 1999 Dec;140(12):5962-70.
Smiles	[Thyrotropin]
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	TSH,Pretiron
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-protein/nucleotide metabolism
Manufacturer - Targets	Apoptosis; PKC; TSH Receptor
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Product Description	Thyrotropin (TSH, Pretiron) is a thyroid-stimulating hormone produced by thyrotrope cells in the anterior pituitary gland. Thyrotropin regulates the endocrine function of the thyroid. Thyrotropin induces transcriptional regulation of TH-gatekeeper genes in tanycytes through the Tshr/Gαq/PKC pathway. Thyrotropin prevents Apoptosis. Thyrotropin has an association of low levels with increased bone remodeling, reduced bone mass and a high fracture risk in mice. Thyrotropin is promising for research of skeletal remodeling, hyperthyroidism[1][2][3][4][13].
Manufacturer - Research Area	Cancer; Endocrinology; Metabolic Disease; Inflammation/Immunology
Solubility	10 mM in DMSO
Manufacturer - Pathway	Apoptosis; Epigenetics; GPCR/G Protein; TGF-beta/Smad
Clinical information	Launched

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HY-107916-100mg-safety-datasheet.pdf