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Dersimelagon

Dersimelagon

Item no.	HY-109114-100mg
Manufacturer	MedChem Express
CASRN	1835256-48-8
Amount	100 mg
Quantity options	100 mg 10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	98.66
Citations	[1]T. Suzuki, et al. Melanogenic effect of dersimelagon (MT-7117), a novel oral melanocortin 1 receptor agonist. Skin Health Dis. 2022; 2(1):e78.\|[2]Erwin AL, et al. Porphyrias in the Age of Targeted Therapies. Diagnostics (Basel). 2021;11(10):1795. Published 2021 Sep 29.
Smiles	O=C(N1C[C@H](C2=C(N3CCC(C(O)=O)CC3)C=C(C(F)(F)F)C=C2)[C@@H](COC)C1)[C@]4([C@H](C5=CC=C(OC)C=C5)CN(C6CCCC6)C4)F
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	MT-7117
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-protein/nucleotide metabolism
Manufacturer - Targets	Melanocortin Receptor
Shipping Temperature	Blue Ice
Storage Conditions	-20°C, 3 years (Powder)
Molecular Weight	675.75
Product Description	Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist with EC50 values of 8.16, 3.91, 1.14 and 0.251 nM for human (h), cynomolgus monkey (cm), mouse (m) and rat (r) MC1R, respectively. Dersimelagon shows good affinity for hMC1R and hMC4R with Ki values of 2.26, 32.9 nM, respectively. Dersimelagon can be used for the research of skin pigmentation[1][2].
Manufacturer - Research Area	Metabolic Disease
Solubility	10 mM in DMSO
Manufacturer - Pathway	GPCR/G Protein; Neuronal Signaling
Clinical information	Phase 3

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-109114-100mg-safety-datasheet.pdf