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12-HETE

12-HETE

Item no.	HY-113439-100ug
Manufacturer	MedChem Express
CASRN	71030-37-0
Amount	100 ug (312.04 uM x 1 mL in Ethanol)
Quantity options	100 ug (312.04 uM x 1 mL in Ethanol) 50 ug (312.04 uM x 0.5 mL in Ethanol)
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	95.70
Citations	[1]Qian Liu, et al. 12-HETE facilitates cell survival by activating the integrin-linked kinase/NF-κB pathway in ovarian cancer. Cancer Manag Res. 2018 Nov 16;10:5825-5838.\|[2]Benedetta Porro, et al. Analysis, physiological and clinical significance of 12-HETE: a neglected platelet-derived 12-lipoxygenase product. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Aug 1;964:26-40.\|[3]Aidan J Hampson, et al. 12-hydroxyeicosatetrenoate (12-HETE) attenuates AMPA receptor-mediated neurotoxicity: evidence for a G-protein-coupled HETE receptor. J Neurosci. 2002 Jan 1;22(1):257-64.
Smiles	CCCCC/C=C\CC(O)/C=C/C=C\C/C=C\CCCC(O)=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Apoptosis
Shipping Temperature	Blue Ice
Storage Conditions	Solution, -20°C, 2 years
Molecular Weight	320.47
Product Description	12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway[1].12-HETE has both anti-thrombotic and pro-thrombotic effects[2]. 12-HETE is a neuromodulator[3].
Manufacturer - Research Area	Inflammation/Immunology; Cardiovascular Disease
Solubility	10 mM in DMSO
Manufacturer - Pathway	Apoptosis
Clinical information	No Development Reported

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HY-113439-100ug-safety-datasheet.pdf