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Trimethylamine-N-oxide-13C3

Trimethylamine-N-oxide-13C3

Item no.	HY-116084S1-5mg
Manufacturer	MedChem Express
Amount	5 mg
Quantity options	1 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Citations	[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. \|[2]Wei Shuai, et al. High-choline Diet Exacerbates Cardiac Dysfunction, Fibrosis, and Inflammation in a Mouse Model of Heart Failure With Preserved Ejection Fraction. J Card Fail. 2020 May 14;S1071-9164(19)31802-0.\|[3]Wenlong Yang, et al. Gut Microbe-Derived Metabolite Trimethylamine N-oxide Accelerates Fibroblast-Myofibroblast Differentiation and Induces Cardiac Fibrosis. J Mol Cell Cardiol. 2019 Sep;134:119-130.\|[4]Manuel T Velasquez, et al. Trimethylamine N-Oxide: The Good, the Bad and the Unknown. Toxins (Basel). 2016 Nov 8;8(11):326.
Smiles	[13CH3][N+]([13CH3])([O-])[13CH3]
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Isotope-Labeled Compounds
Manufacturer - Targets	Endogenous Metabolite; Isotope-Labeled Compounds; NOD-like Receptor (NLR); Reactive Oxygen Species (ROS); TGF-beta/Smad
Shipping Temperature	Room temperature
Molecular Weight	78.09
Product Description	Trimethylamine-N-oxide-13C3 is the 13C-labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway[1][2][3].
Manufacturer - Research Area	Inflammation/Immunology; Cardiovascular Disease
Solubility	10 mM in DMSO
Manufacturer - Pathway	Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others; Stem Cell/Wnt; TGF-beta/Smad
Clinical information	No Development Reported

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5 mg

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