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Sonidegib metabolite M48

Sonidegib metabolite M48

Item no.	HY-117229-100mg
Manufacturer	MedChem Express
CASRN	1221722-10-6
Amount	100 mg
Quantity options	100 mg 1 ea 25 mg 50 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	98.0
Citations	[1]Markus Zollinger, et al. Absorption, distribution, metabolism, and excretion (ADME) of ¹⁴C-sonidegib (LDE225) in healthy volunteers. Cancer Chemother Pharmacol. 2014 Jul;74(1):63-75.
Smiles	O=C(O)C1=C(C(C2=CC=C(C=C2)OC(F)(F)F)=CC=C1)C
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Drug Metabolite
Shipping Temperature	Room Temperature
Storage Conditions	Store at room temperature 3 years
Molecular Weight	296.24
Product Description	Sonidegib metabolite M48 is the main circulating metabolite of Sonidegib. Sonidegib is a hedgehog pathway inhibitor. M48 showed a much longer Tmax (60 h) than Sonidegib[1].
Manufacturer - Research Area	Cancer
Solubility	10 mM in DMSO
Manufacturer - Pathway	Metabolic Enzyme/Protease
Clinical information	No Development Reported

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