MM-102

Item no.	HY-12220-100mg
Manufacturer	MedChem Express
CASRN	1417329-24-8
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.39
Citations	[1]Karatas H, et al. High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J Am Chem Soc. 2013, 135(2), 669-682.\|[2]Townsend E C. Development of a Novel Inhibitor to the Conserved, Developmental Regulator, WDR5, for Treatment of Acute Leukemia[D]. , 2012.\|[3]Wang D, et al. MBD2 regulates the progression and chemoresistance of cholangiocarcinoma through interaction with WDR5[J]. Journal of Experimental & Clinical Cancer Research, 2024, 43(1): 272.\|[4]Hara D, et al. Inhibition of H3K4 Trimethylation Ameliorates Peritoneal Fibrosis and Senescence: FR-PO456[J]. Journal of the American Society of Nephrology, 2022, 33(11S): 447-448.\|[5]Zhang Z, et al. Down-regulation of H3K4me3 by MM-102 facilitates epigenetic reprogramming of porcine somatic cell nuclear transfer embryos[J]. Cellular Physiology and Biochemistry, 2018, 45(4): 1529-1540. Acta Pharmacol Sin. 2021 Apr 13.\|Cell Death Dis. 2022 Sep 6;13(9):770.\|J Mol Endocrinol. 2021 Jan;66(1):45-57.\|Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2961-2966.
Smiles	O=C(C1(NC([C@@H](NC(C(NC(C(C)C)=O)(CC)CC)=O)CCCNC(N)=N)=O)CCCC1)NC(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	HMTase Inhibitor IX
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Apoptosis; Interleukin Related; NF-κB; TNF Receptor; WDR5
Shipping Temperature	Blue Ice
Storage Conditions	-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Molecular Weight	669.80
Product Description	MM-102 (HMTase Inhibitor IX) is a cell-permeable and tightly binding inhibitor of MLL1-WDR5 interaction (IC50=2.4 nM). MM-102 can specifically inhibit the growth and induce apoptosis of leukemia cells containing MLL1 fusion protein, and reduce renal fibrosis and inflammation in mice with ischemia-reperfusion injury. In addition, MM-102 also acts as an H3K4 histone methyltransferase inhibitor to improve the development of porcine somatic cell nuclear transfer (SCNT) embryos[1][2][3][4][5].
Manufacturer - Research Area	Cancer; Inflammation/Immunology
Solubility	DMSO: 125 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Epigenetics; Immunology/Inflammation; NF-κB
Clinical information	No Development Reported

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HY-12220-100mg-safety-datasheet.pdf