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Siponimod (hemifumarate)

Siponimod (hemifumarate)

Item no.	HY-12355A-100mg
Manufacturer	MedChem Express
CASRN	1234627-85-0
Amount	100 mg
Quantity options	100 mg 1 ea 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.64
Citations	[1]Pan S, et al. Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator. ACS Med Chem Lett. 2013 Jan 4;4(3):333-7.\|[2]McGinley M, et al. Prospects of siponimod in secondary progressive multiple sclerosis. Ther Adv Neurol Disord. 2018 Jul 17;11:1756286418788013.\|[3]Behrangi N, et al. Mechanism of Siponimod: Anti-Inflammatory and Neuroprotective Mode of Action. Cells. 2019 Jan 7;8(1):24.
Smiles	O=C(C1CN(CC2=CC=C(/C(C)=N/OCC3=CC=C(C4CCCCC4)C(C(F)(F)F)=C3)C=C2CC)C1)O.OC(/C=C/C(O)=O)=O.[1/2]
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	BAF-312 (hemifumarate)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	LPL Receptor
Shipping Temperature	Room temperature
Storage Conditions	-20°C (Powder, sealed storage, away from moisture)
Molecular Weight	574.63
Product Description	Siponimod (BAF-312) hemifumarate is a potent and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod hemifumarate is selective for S1P1 and S1P5 receptors over S1P2, S1P3, and S1P4 (EC50s of 0.39, 0.98, >10000, >1000, and 750 nM, respectively). Siponimod hemifumarate can be used for multiple sclerosis (MS) research[1][2].
Manufacturer - Research Area	Inflammation/Immunology; Neurological Disease
Solubility	DMSO: 12.5 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein
Isoform	S1PR1; S1PR2; S1PR3; S1PR4; S1PR5
Clinical information	Launched

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