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GS-443902

GS-443902

Item no.	HY-126303-100mg
Manufacturer	MedChem Express
CASRN	1355149-45-9
Amount	100 mg
Quantity options	100 mg 10 mg 1 ea 1 mg 25 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.87
Citations	Acta Pharm Sin B. 2021 Mar 22. Cell. 2022 Nov 10;185(23):4347-4360.e17. Chem Biol Interact. 2021 Apr 19;109480. Current Research in Pharmacology and Drug Discovery. 2021, 100045. Int J Mol Sci. 2022, 23(15), 8302. Research Square Preprint. 2022 May. bioRxiv. 2021 Jul 21:2021.07.21.453274. J Med Chem. 2024 May 1. Nat Commun. 2021 Oct 4;12(1):5811. Sci Rep. 2022 Nov 2;12(1):18506. [1]Siegel D, et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. Med Chem. 2017 Mar 9;60(5):1648-1661. [2]Cho A, et al. Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2705-7. [3]Warren TK, et al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature. 2016 Mar 17;531(7594):381-5.
Smiles	O=P(OP(O)(O)=O)(O)OP(OC[C@@H](O1)[C@@H](O)[C@@H](O)[C@]1(C#N)C2=CC=C3N2N=CN=C3N)(O)=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	GS-441524 triphosphate,Remdesivir metabolite
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-anti-virus
Manufacturer - Targets	DNA/RNA Synthesis; Drug Metabolite; HCV; RSV; SARS-CoV
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, stored under nitrogen)
Molecular Weight	531.20
Product Description	GS-443902 (GS-441524 triphosphate) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 μM, 5 μM for RSV RdRp and HCV RdRp, respectively. GS-443902 is the active triphosphate metabolite of Remdesivir[1][2].
Manufacturer - Research Area	Infection
Solubility	H2O : 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-126303-100mg-safety-datasheet.pdf