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(4R,5S)-Nutlin carboxylic acid

(4R,5S)-Nutlin carboxylic acid

Item no.	HY-128836-2g
Manufacturer	MedChem Express
CASRN	2306390-08-7
Amount	2g
Quantity options	1g 2g
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Formula	C32H32Cl2N4O6
Citations	[1]Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575.
Smiles	O=C1N(CC(O)=O)CCN(C(N2[C@@H](C3=CC=C(Cl)C=C3)[C@@H](C4=CC=C(Cl)C=C4)N=C2C5=CC=C(OC)C=C5OC(C)C)=O)C1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	MDM2 ligand 2, E3 ligase Ligand 15
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Ligands for E3 Ligase
Shipping Temperature	Room Temperature
Molecular Weight	639.53
Product Description	(4R, 5S)-Nutlin carboxylic acid (MDM2 ligand 2) is the Nutlin 3-based MDM2 ligand. (4R, 5S)-Nutlin carboxylic acid can be connected to the ligand for protein by a linker to form PROTACs[1].
Manufacturer - Research Area	Cancer
Solubility	10 mM in DMSO
Manufacturer - Pathway	PROTAC
Isoform	MDM2
Clinical information	No Development Reported

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