P32/98

Item no.	HY-129736A-100mg
Manufacturer	MedChem Express
CASRN	136259-20-6
Amount	100 mg
Quantity options	100 mg 1 ea
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Citations	[1]Augstein P, et al. Efficacy of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide (P32/98) in fatty Zucker rats with incipient and manifest impaired glucose tolerance. Diabetes Obes Metab. 2008;10(10):850-861. [2]Wargent E, et al. Improvement of glucose tolerance in Zucker diabetic fatty rats by long-term treatment with the dipeptidyl peptidase inhibitor P32/98: comparison with and combination with rosiglitazone. Diabetes Obes Metab. 2005;7(2):170-181. [3]Schlatter P, et al. Glucagon-like peptide 1 receptor expression in primary porcine proximal tubular cells. Regul Pept. 2007 Jun 7;141(1-3):120-8.
Smiles	CC[C@H](C)[C@H](N)C(N1CSCC1)=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Targets	Dipeptidyl Peptidase
Shipping Temperature	Room temperature
Molecular Weight	202.32
Product Description	P32/98 a potent inhibitor of dipeptidyl peptidase IV with a Ki value of 130 nM. P32/98 improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model[1][2][3].
Manufacturer - Research Area	Metabolic Disease
Solubility	10 mM in DMSO
Manufacturer - Pathway	Metabolic Enzyme/Protease
Isoform	DPP-4
Clinical information	Phase 2

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