HBDDE

Item no.	HY-131305-100mg
Manufacturer	MedChem Express
CASRN	154675-18-0
Amount	100 mg
Quantity options	100 mg 10 mg 1 ea 1 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	98.03
Citations	[1]A Mathur, et al. 2,2',3,3',4,4'-Hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether (HBDDE)-induced neuronal apoptosis independent of classical protein kinase C alpha or gamma inhibition. Biochem Pharmacol. 2000 Sep 15;60(6):809-15.\|[2]Y Kashiwada, et al. New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C. J Med Chem. 1994 Jan 7;37(1):195-200.
Smiles	OC1=CC(COC)=C(C2=C(C(O)=C(C=C2COC)O)O)C(O)=C1O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neurodegeneration
Manufacturer - Targets	Apoptosis; PKC
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	338.31
Product Description	HBDDE, a derivative of Ellagic acid, is an isoform-selective PKCα and PKCγ inhibitor with IC50s of 43 μM and 50 μM, respectively. HBDDE shows selective for PKCα/PKCγ over PKCδ, PKCβI and PKCβII isozymes. HBDDE induces neuronal apoptosis[1][2].
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO: 5 mg/mL (ultrasonic; warming)
Manufacturer - Pathway	Apoptosis; Epigenetics; TGF-beta/Smad
Isoform	PKCα; PKCγ
Clinical information	No Development Reported

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HY-131305-100mg-safety-datasheet.pdf