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Hydroxy desmethyl Bosentan

Hydroxy desmethyl Bosentan

Item no.	HY-135390-100mg
Manufacturer	MedChem Express
CASRN	253688-62-9
Amount	100 mg
Quantity options	100 mg 1 ea 1 mg 500 ug
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Citations	[1]Lepri S, et al. Metabolism study and biological evaluation of bosentan derivatives. Eur J Med Chem. 2016 Oct 4;121:658-670.\|[2]Dhillon S, et al. Bosentan: a review of its use in the management of mildly symptomatic pulmonary arterial hypertension. Am J Cardiovasc Drugs. 2009;9(5):331-50.
Smiles	O=S(C1=CC=C(C(C)(C)CO)C=C1)(NC2=NC(C3=NC=CC=N3)=NC(OCCO)=C2OC4=CC=CC=C4O)=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	Ro 64-1056
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Drug Metabolite
Shipping Temperature	Room temperature
Molecular Weight	553.59
Product Description	Hydroxy desmethyl Bosentan (Ro 64-105) is a Bosentan metabolism produced by the cytochrome P450 enzymes CYP2C9 and CYP3A4 in the liver[1]. Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively. Bosentan can be used in treatment of pulmonary arterial hypertension[2].
Manufacturer - Research Area	Cardiovascular Disease
Solubility	10 mM in DMSO
Manufacturer - Pathway	Metabolic Enzyme/Protease
Clinical information	No Development Reported

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