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AZ13824374

AZ13824374

Item no.	HY-136521-5mg
Manufacturer	MedChem Express
CASRN	3040082-19-4
Amount	5 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 25 mg 2 mg 5 mg
Category	Reagents & Chemicals Other Chemicals
Type	Reagents
Specific against	other
Purity	99.22
Citations	[1]Winter-Holt JJ, et al. Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models. J Med Chem. 2022 Feb 24;65(4):3306-3331.
Smiles	O=C1N[C@H](C(C)C)[C@H]2C3=CC=CC=C3C[C@@H]1N2C(C4=NN5C(C(NC6CCN(CC(C)(F)C)CC6)=C4)=NN=C5C)=O
ECLASS 10.1	42051003
ECLASS 11.0	42051003
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Epigenetic Reader Domain
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	562.68
Product Description	AZ13824374 is a potent and selective ATAD2 bromodomain inhibitor (pIC50 of 6.9 in HCT116 cells). AZ13824374 disrupts chromatin interactions and gene transcription by binding to the acetyl-lysine binding site of the ATAD2 bromodomain. AZ13824374 has anticancer activity against breast cancer[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO: ≥ 200 mg/mL
Manufacturer - Pathway	Epigenetics
Clinical information	No Development Reported

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HY-136521-5mg-safety-datasheet.pdf