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MC-VC-PABC-amide-PEG1-CH2-CC-885

MC-VC-PABC-amide-PEG1-CH2-CC-885

Item no.	HY-145448-100mg
Manufacturer	MedChem Express
CASRN	2722697-82-5
Amount	100 mg
Quantity options	100 mg 10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.93
Citations	[1]Mary E. Matyskiela, et al. A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase. Nature. 2016 Jul 14;535(7611):252-7.\|[2]Neodegrader conjugates. World Intellectual Property Organization, WO2021198965 A1 2021-10-07.\|[3]Neodegrader conjugates. World Intellectual Property Organization, WO2024075080 A1 2024-04-11.
Smiles	O=C1C2=CC=C(CNC(NC3=CC(Cl)=C(C=C3)CCOCCN(C)C(OCC4=CC=C(C=C4)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN5C(C=CC5=O)=O)=O)=O)=O)=O)=O)C=C2CN1C6C(NC(CC6)=O)=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	E3 Ligase Ligand-Linker Conjugates
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, protect from light)
Molecular Weight	1126.65
Product Description	MC-VC-PABC-amide-PEG1-CH2-CC-885 (compound I-1) is a neoDegrader-Linker conjugate, consists of the GSPT1 degrader/molecular glue CC-885 (HY-101488) and a linker. MC-VC-PABC-amide-PEG1-CH2-CC-885 can be conjugated to the antibody DAR3.7 that specifically targets CD56 to synthesize Antibody-Drug Conjugates (ADCs)[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	PROTAC
Clinical information	No Development Reported

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HY-145448-100mg-safety-datasheet.pdf