« Back
Home /
Mufemilast

Mufemilast

Item no.	HY-145583-100mg
Manufacturer	MedChem Express
CASRN	1255909-03-5
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.67
Citations	[1]Liu Tian, et al., Efficacy and Safety of Mufemilast in Patients with Behçet's Syndrome: A Phase 2, Double-Blind, Placebo-Controlled Trial. \|[2]Yilmaz, O., et al., (2024). New and emerging oral therapies for psoriasis. Drugs in context, 13, 2024-5-6.\|[3]Peng, T., et al., (2020). Advances in the Development of Phosphodiesterase-4 Inhibitors. Journal of medicinal chemistry, 63(19), 10594–10617.\|[4]Liu, X., et al., (2018). Determination of a PDE4 inhibitor Hemay005 in human plasma and urine by UPLC-MS/MS and its application to a PK study. Bioanalysis, 10(11), 863–875. \|[5]Liu, X., et al., (2018). Determination of a PDE4 inhibitor Hemay005 in human plasma and urine by UPLC-MS/MS and its application to a PK study. Bioanalysis, 10(11), 863–875.
Smiles	O=C1C2=C(NC(C)=O)SC=C2C(N1[C@@H](C3=CC(OCC)=C(C=C3)OC)CS(C)(=O)=O)=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	Hemay005
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-protein/nucleotide metabolism
Manufacturer - Targets	Phosphodiesterase (PDE)
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	466.53
Product Description	Mufemilast (Heymay005) is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor (IC50 = 80-120 nM). Mufemilast modulates cytokines upregulated in Behςet’s syndrome (BS). Mufemilast displays a significant inhibitory effect on TNF-α, which is an important proinflammatory cytokine target in the disease process of psoriasis. Mufemilast can be studied in research for diseases such as rheumatoid arthritis, psoriasis and BS[1][2][3][4][5].
Manufacturer - Research Area	Inflammation/Immunology; Others
Solubility	DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Metabolic Enzyme/Protease
Isoform	PDE4
Clinical information	Phase 3

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

HY-145583-100mg-safety-datasheet.pdf