Comparison

Topoisomerase IIα-IN-2 European Partner

Item no. HY-146021-100mg
Manufacturer MedChem Express
CASRN 2407521-90-6
Amount 100 mg
Quantity options 100 mg 1 ea
Category
Type Chemicals
Specific against other
Citations [1]Pedatella S, et al. Antitumor agents 7. Synthesis, antiproliferative activity and molecular modeling of new l-lysine-conjugated pyridophenoxazinones as potent DNA-binding ligands and topoisomerase IIα inhibitors. Eur J Med Chem. 2020 Feb 1;187:111960.
Smiles O=C1C2=NC=CC=C2C(C(OC3=C4)=C1)=NC3=CC=C4C(NCCCC[C@H](N)C(O)=O)=O
ECLASS 10.1 32160000
ECLASS 11.0 32160000
UNSPSC 12000000
Shipping Condition Room temperature
Available
Manufacturer - Type
Reference compound
Manufacturer - Applications
Cancer-programmed cell death
Manufacturer - Targets
Topoisomerase
Shipping Temperature
Room temperature
Molecular Weight
420.42
Product Description
Topoisomerase IIα-IN-2 (compound 5) is a potent DNA-binding ligands and topoisomerase IIα inhibitor. Topoisomerase IIα-IN-2 exhibits high antiproliferative activity against human cancer cell lines. Topoisomerase IIα-IN-2 significantly induces DNA damage and arrests cancer cells at G2/M phase[1].
Manufacturer - Research Area
Cancer
Solubility
10 mM in DMSO
Manufacturer - Pathway
Cell Cycle/DNA Damage
Isoform
Topo II
Clinical information
No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 mg
Available: In stock
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