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BOLD-100 (free base)

BOLD-100 (free base)

Item no.	HY-147039-5mg
Manufacturer	MedChem Express
CASRN	783324-98-1
Amount	5 mg
Quantity options	100 mg 10 mg 1 ea 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Citations	[1]Baier D, et al. The Anticancer Ruthenium Compound BOLD-100 Targets Glycolysis and Generates a Metabolic Vulnerability towards Glucose Deprivation. Pharmaceutics. 2022;14(2):238. Published 2022 Jan 20.
Smiles	[Cl-][Ru+4]([Cl-])([Cl-])([N]1=CC2=CC=CC=C2N1)([N]3=CC4=CC=CC=C4N3)[Cl-]
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	NKP-1339 (free base),IT-139 (free base),KP-1339 (free base)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Autophagy; HSP
Shipping Temperature	Room temperature
Molecular Weight	479.15
Product Description	BOLD-100 (NKP-1339; IT-139) free base is a ruthenium-based anticancer agent. BOLD-100 free base also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 free base interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution[1].
Manufacturer - Research Area	Cancer
Solubility	10 mM in DMSO
Manufacturer - Pathway	Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Clinical information	Phase 2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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