M1069

Item no.	HY-148088-1mg
Manufacturer	MedChem Express
CASRN	3027658-65-4
Amount	1 mg
Quantity options	100 mg 10 mg 1 ea 1 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Other Chemicals
Type	Reagents
Specific against	other
Purity	98.04
Citations	[1]Rinat Zaynagetdinov, et al. Abstract 3499: M1069 as dual A2A/A2B adenosine receptor antagonist counteracts immune-suppressive mechanisms of adenosine and reduces tumor growth in vivo. Cancer Res (2022) 82 (12_Supplement):3499. \|[2]Lillian L Siu, et al. Abstract CT240: A first-in-human study of the dual A2A/A2B adenosine receptor antagonist M1069 in patients with advanced solid tumors. Cancer Res (2022) 82 (12_Supplement):CT240. \|[3]Tanzer Eva-Maria, et al. Preparation of thiazolopyridine derivatives as adenosine receptor antagonists: World Intellectual Property Organization, WO2020152132[P]. 2020-07-30.
Smiles	COC1=C2C(SC(NC(N3C[C@]4(CCCOC4)CC3)=O)=N2)=C(C5=CCOCC5)C=N1.O=C(O)/C=C/C(O)=O
ECLASS 10.1	42051003
ECLASS 11.0	42051003
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Adenosine Receptor
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	546.59
Product Description	M1069 is a selective and orall active, dual A2A/A2B adenosine receptor antagonist with a selectivity of >100 fold against the A1 and A3 receptors. M1069 counteracts immune-suppressive mechanisms of adenosine, and exhibits anti-tumor activity[1][2][3].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	GPCR/G Protein
Isoform	Adenosine A2A receptor (A2AR); Adenosine A2B receptor (A2BR)
Clinical information	Phase 1

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HY-148088-1mg-safety-datasheet.pdf