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Alosetron ((Z)-2-butenedioate)

Alosetron ((Z)-2-butenedioate)

Item no.	HY-70050B-100mg
Manufacturer	MedChem Express
CASRN	122852-43-1
Amount	100 mg
Quantity options	100 mg 10 mg 1 ea 50 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Citations	[1]Balfour JA, Goa KL, Perry CM. Alosetron. Drugs. 2000;59(3):511-520. [2]Motavallian A, et al. Anti-inflammatory effects of alosetron mediated through 5-HT3 receptors on experimental colitis. Res Pharm Sci. 2019;14(3):228-236.
Smiles	O=C(C(C1=C2C=CC=C1)=C(N2C)CC3)N3CC4=C(NC=N4)C.O=C(/C=C\C(O)=O)O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	GR 68755 ((Z)-2-butenedioate),GR 68755X ((Z)-2-butenedioate)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	5-HT Receptor
Shipping Temperature	Room temperature
Molecular Weight	410.42
Product Description	Alosetron (GR 68755) (Z)-2-butenedioate is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron (Z)-2-butenedioate is used for the research of irritable bowel syndrome (IBS). Alosetron (Z)-2-butenedioate blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron (Z)-2-butenedioate attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects[1][2].
Manufacturer - Research Area	Inflammation/Immunology; Neurological Disease
Solubility	10 mM in DMSO
Manufacturer - Pathway	GPCR/G Protein; Neuronal Signaling
Isoform	lactoferrin
Clinical information	Launched

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