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Zonisamide (sodium)

Zonisamide (sodium)

Item no.	HY-B0124A-100mg
Manufacturer	MedChem Express
CASRN	68291-98-5
Amount	100 mg
Quantity options	100 mg 1 ea 200 mg 500 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Citations	[1]Kawajiri S, et al. Zonisamide reduces cell death in SH-SY5Y cells via an anti-apoptotic effect and by upregulating MnSOD. Neurosci Lett. 2010 Sep 6;481(2):88-91. \|[2]Ueda Y, et al. Effect of zonisamide on molecular regulation of glutamate and GABA transporter proteins during epileptogenesis in rats with hippocampal seizures. Brain Res Mol Brain Res. 2003 Aug 19;116(1-2):1-6. \|[3]Wu Q, et al. Zonisamide alleviates cardiac hypertrophy in rats by increasing Hrd1 expression and inhibiting endoplasmic reticulum stress. Acta Pharmacol Sin. 2021 Oct;42(10):1587-1597. \|[4]De Simone G, et al. Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies. Bioorg Med Chem Lett. 2005 May 2;15(9):2315-20.
Smiles	O=S(CC1=NOC2=C1C=CC=C2)([NH-])=O.[Na+]
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	AD 810 sodium,CI 912 sodium
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neurodegeneration
Manufacturer - Category	Reference compound / Active compounds; API
Manufacturer - Targets	Apoptosis; Carbonic Anhydrase
Manufacturer - HS Code	H302
Shipping Temperature	Room temperature
Molecular Weight	234.21
Product Description	Zonisamide (AD 810) sodium is an orally active carbonic anhydrase inhibitor, with Kis of 35.2 and 20.6 nM for hCA II and hCA V, respectively. Zonisamide sodium exerts neuroprotective effects through anti-apoptosis and upregulating MnSOD levels. Zonisamide sodium also increases the expression of Hrd1, thereby improving cardiac function in AAC rats. Zonisamide sodium can be used in studies of seizure, parkinson’s disease and cardiac hypertrophy[1][2][3][4].
Manufacturer - Research Area	Neurological Disease; Cardiovascular Disease
Solubility	10 mM in DMSO
Manufacturer - Pathway	Apoptosis; Metabolic Enzyme/Protease
Clinical information	Launched
Isoform	CA Ⅱ
UNSPSC Code	12352005
Precautionary	P264-P270-P330-P501

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