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Ranitidine (bismuth citrate)

Ranitidine (bismuth citrate)

Item no.	HY-B0693A-100mg
Manufacturer	MedChem Express
CASRN	128345-62-0
Amount	100 mg
Quantity options	100 mg 1 ea
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Citations	[1]Herling AW, et al. Inhibition of 14C-aminopyrine accumulation in isolated rabbit gastric glands by the H2-receptor antagonist HOE 760 (TZU-0460). Agents Actions. 1987 Feb. 20(1-2):35-9. [2]Yuan S, et al. Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters. Nat Microbiol. 2020 Nov. 5(11):1439-1448. [3]Lambert JR, et al. The actions of bismuth in the treatment of Helicobacter pylori infection. Aliment Pharmacol Ther. 1997 Apr. 11(Suppl 1):27-33. [4]Stables R, et al. Gastric anti-secretory, mucosal protective, anti-pepsin and anti-Helicobacter properties of ranitidine bismuth citrate. Aliment Pharmacol Ther. 1993 Jun. 7(3):237-46.
Smiles	O=[N+](/C=C(NC)/NCCSCC1=CC=C(CN(C)C)O1)[O-].O=C(CC(C([O-])=O)(O)CC([O-])=O)[O-].[Bi+3]
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-anti-virus
Manufacturer - Targets	Bacterial; Histamine Receptor; SARS-CoV
Shipping Temperature	Room temperature
Molecular Weight	712.48
Product Description	Ranitidine bismuth citrate is an orally active Histamine H2-receptor antagonist with an IC50 of 3.3 μM. Ranitidine bismuth citrate has high selectivity for SARS-CoV-2-infected cells. Ranitidine bismuth citrate is a commonly used agent anti-Helicobacter pylori infection with an MIC90 value of 16 ng/L[1][2][3].
Manufacturer - Research Area	Infection
Solubility	10 mM in DMSO
Manufacturer - Pathway	Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Isoform	H2 Receptor
Clinical information	Launched

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Amount: 100 mg

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