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Doxepin

Doxepin

Item no.	HY-B0725A-100mg
Manufacturer	MedChem Express
CASRN	1668-19-5
Amount	100 mg
Quantity options	100 mg 1 ea
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Citations	J Appl Toxicol. 2023 Apr 14. Nat Commun. 2022 Nov 10;13(1):6796. Cell Commun Signal. 2023 May 25;21(1):123. Virus Res. 2022 Aug;317:198816. [1]AnnemiekVermeeren, et al. Effects of the use of hypnotics on cognition. Progress in brain research vol. 190 (2011): 89-103. [2]G Hajak, et al. Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study. The Journal of clinical psychiatry vol. 62,6 (2001): 453-63. [3]Mahsa Gharzi, et al. Effects of different doses of doxepin on passive avoidance learning in rats. Advanced biomedical research vol. 2 66. 30 Jul. 2013. [4]Jimei Bu, et al. Mechanism underlying the effects of doxepin on β-amyloid -induced memory impairment in rats. Iran J Basic Med Sci. 2017 Sep;20(9):1044-1049.
Smiles	CN(C)CC/C=C1C2=CC=CC=C2OCC3=CC=CC=C/13
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neurodegeneration
Manufacturer - Targets	Akt; mTOR; PI3K
Shipping Temperature	Room temperature
Molecular Weight	279.38
Product Description	Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclic antidepressant. Doxepin has therapeutic effects in atopic dermatitis, chronic urticarial, can improve cognitive processes, protect central nervous system. Doxepin has also been proposed as a protective factor against oxidative stress[1][2][3].
Manufacturer - Research Area	Neurological Disease; Cancer
Solubility	10 mM in DMSO
Manufacturer - Pathway	PI3K/Akt/mTOR
Clinical information	Launched

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