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Eflornithine

Eflornithine

Item no.	HY-B0744-100mg
Manufacturer	MedChem Express
CASRN	70052-12-9
Amount	100 mg
Quantity options	100 mg 10 mg 1 ea 500 mg 50 mg
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	98.0
Formula	C6H12F2N2O2
Citations	bioRxiv. 2024 Jan 15. Cancer Nanotechnol. 2023 May 9. Commun Biol. 2019 May 8;2:171. Food Biosci. 2023 Oct, 55, 102970. JACC Basic Transl Sci. 2022 Aug 3;7(8):820-840. Nat Commun. 2024 Mar 19;15(1):2461. Oncotargets Ther. 2020 Nov 17;13:11697-11709. RSC Adv. 2019, 9, 11026-11037. Front Oncol. 2021 Mar 11;11:636373. Sci Adv. 2023 May 19;9(20):eade0718. [1]Burri C, et al. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003 Jun;90 Supp 1:S49-52. [2]Balfour JA, et al. Topical eflornithine. Am J Clin Dermatol. 2001;2(3):197-201; discussion 202. [3]Kumar A, et al. A method to improve the efficacy of topical eflornithine hydrochloride cream. Drug Deliv. 2016 Jun;23(5):1495-501. [4]Lipke DW, et al. Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. Clin Exp Hypertens. 1997 Apr;19(3):297-312.
Smiles	NC(CCCN)(C(F)F)C(O)=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	DFMO, MDL71782, RMI71782, α-difluoromethylornithine
Shipping condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Parasite
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	182.17
Product Description	Eflornithine is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.
Manufacturer - Research Area	Infection; Cancer
Solubility	H2O : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Anti-infection
Isoform	Trypanosoma
Clinical information	Launched

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-B0744-100mg-safety-datasheet.pdf