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DiSC3(5)

DiSC3(5)

Item no.	HY-D0085-100mg
Manufacturer	MedChem Express
CASRN	53213-94-8
Amount	100 mg
Quantity options	100 mg 1 ea 25 mg 50 mg
Category	Reagents & Chemicals Staining & Dyes
Type	Reagents
Specific against	other
Purity	99.83
Formula	C25H27IN2S2
Citations	[1]Yamamoto T, et al. Multiple effects of DiS-C3(5) on mitochondrial structure and function. Eur J Biochem. 2004;271(17):3573-3579. [2]Sims PJ, et al. Studies on the mechanism by which cyanine dyes measure membrane potential in red blood cells and phosphatidylcholine vesicles. Biochemistry. 1974 Jul 30;13(16):3315-30. [3]Smith TC, et al. The effect of the fluorescent probe, 3,3'-dipropylthiodicarbocyanine iodide, on the membrane potential of Ehrlich ascites tumor cells. Biochem Biophys Res Commun. 1980 Jul 31;95(2):722-7.
Smiles	CCCN1/C(SC2=CC=CC=C12)=C\C=C\C=C\C3=[N+](CCC)C4=CC=CC=C4S3.[I-]
ECLASS 10.1	42051003
ECLASS 11.0	42051003
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Dye Reagents
Manufacturer - Targets	Fluorescent Dye
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	546.53
Product Description	DiSC3(5) is a fluorescent probe commonly used as a tracer dye to evaluate mitochondrial membrane potential. The excitation/emission wavelength of DiSC3(5) is up to 622/670 nm. DiSC3(5) can inhibit the respiratory system associated with mitochondrial NAD, and the IC50 value is 8 μM. DiSC3(5) in the presence of Na+/K+-ATPase inhibitor ouabain 2 can induce membrane hyperpolarization of Ehrlich ascites tumor cells[1][2][3].
Manufacturer - Research Area	Others
Solubility	DMSO : 5.83 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Others
Clinical information	No Development Reported

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HY-D0085-100mg-safety-datasheet.pdf