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Santamarine

Santamarine

Item no.	HY-N1326-100mg
Manufacturer	MedChem Express
CASRN	4290-13-5
Amount	100 mg
Quantity options	100 mg 1 ea
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Citations	[1]Choi HG, et al. Santamarin, a sesquiterpene lactone isolated from <i>Saussurea lappa</i>, represses LPS-induced inflammatory responses via expression of heme oxygenase-1 in murine macrophage cells. Int Immunopharmacol. 2012;13(3):271-279. [2]Oh JH, et al. Santamarine Shows Anti-Photoaging Properties via Inhibition of MAPK/AP-1 and Stimulation of TGF-β/Smad Signaling in UVA-Irradiated HDFs. Molecules. 2021;26(12):3585. Published 2021 Jun 11.
Smiles	O=C(O[C@@]1([H])[C@@]2([H])CC[C@@]3(C)[C@H](O)CC=C(C)[C@@]31[H])C2=C
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Alias	Santamarin,Balchanin
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Keap1-Nrf2
Shipping Temperature	Room temperature
Molecular Weight	248.32
Product Description	Santamarine (Santamarin), a sesquiterpene lactone, increases HO-1 expression through Nrf2 translocation and suppresses NO, PGE2, TNF-α, and IL-1β production through inhibition of NF-κB translocation in LPS-induced macrophages. Santamarine shows anti-photoaging properties via inhibition of MAPK/AP-1 and stimulation of TGF-β/Smad signaling in UVA-irradiated human dermal fibroblasts (HDFs). Antioxidant activities[1][2].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	10 mM in DMSO
Manufacturer - Pathway	NF-κB
Clinical information	No Development Reported

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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