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Concanamycin A

Concanamycin A

Item no.	HY-N1724-1mg
Manufacturer	MedChem Express
CASRN	80890-47-7
Amount	1 mg
Quantity options	100 ug 1 mg 25 ug 50 ug
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	99.0
Citations	[1]Togashi K, et al. Concanamycin A, a vacuolar type H(+)-ATPase inhibitor, induces cell death in activated CD8(+) CTL. Cytotechnology. 1997 Nov;25(1-3):127-35. [2]Eswarappa SM, et al. Folimycin (concanamycin A) inhibits LPS-induced nitric oxide production and reduces surface localization of TLR4 in murine macrophages. Innate Immun. 2008 Feb;14(1):13-24. [3]Hines IN, et al. Impaired T cell-mediated hepatitis in peroxisome proliferator activated receptor alpha (PPARα)-deficient mice. Biol Res. 2018 Feb 15;51(1):5. [4]Woo JT, et al. Isolation, characterization and biological activities of concanamycins as inhibitors of lysosomal acidification. J Antibiot (Tokyo). 1992 Jul;45(7):1108-16. [5]Vaněk, Z., et al. Immunomodulators isolated from microorganisms. Folia Microbiol. 1991. 36:99–111.
Smiles	C[C@H]([C@@](C[C@H]1O[C@@](O[C@H](C)[C@H]2OC(N)=O)([H])C[C@H]2O)(O[C@H](/C=C/C)[C@H]1C)O)[C@H](O)[C@@H]([C@](OC(/C(OC)=C/C(C)=C/[C@H]([C@@H](O)[C@H]3CC)C)=O)([H])[C@H](/C=C/C=C(C[C@H]([C@@H]3O)C)/C)OC)C
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Antibiotic X 4357B; Folimycin; X 4357B
Shipping Condition	Cool pack
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Antibiotic; Bacterial; Proton Pump
Shipping Temperature	Blue Ice
Storage Conditions	-20°C, 3 years (Powder)
Molecular Weight	866.09
Product Description	Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H+-ATPase (V-ATPase) inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research[1]-[5].
Manufacturer - Research Area	Cancer; Infection; Inflammation/Immunology
Solubility	DMSO : ≥ 10 mg/mL\|Methanol : 10 mg/mL (ultrasonic; warming)
Manufacturer - Pathway	Anti-infection; Membrane Transporter/Ion Channel
Isoform	Macrolide
Clinical information	No Development Reported

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HY-N1724-1mg-safety-datasheet.pdf