IL-17A

Item no.	RLT-100-055S
Manufacturer	ReliaTech
Amount	5ug
Category	Neuroscience Neuroinflammation Peptides & Proteins Recombinant Proteins Cell Biology Cell Culture Cytokines
Type	Cytokines and Growth Factors
Format	Lyophilized
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Bovine
Host	E.coli
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Alias	IL17A, IL17, CTLA8, IL-17, IL-17A
Available
NCBI Gene ID	3605
Uniprot	Q16552
Biological Activity	Assay #1: The ED50 as determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblasts was found to be approximately 2 ng/ml. Assay #2: Measured by its ability to induce IL-6 production by NHDF cells.
Description	The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimer. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant human IL-17A is a 31.0 kDa disulfide-linked homodimer of two 136 amino acid polypeptide chains.
Endotoxin Levels	< 0.1 ng/µg of protein (<1EU/µg)
Length [aa]	136
Molecular Weight	31 kDa
mRNA RefSeq	NM_002190.2
Protein RefSeq	NP_002181.1
Protein Sequence	MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA
Purity Confirmation	> 98% by SDS-PAGE & HPLC analyses
Synonyms	IL17A; IL17; CTLA8; IL-17; IL-17A
Uniprot ID	Q16552

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