LIGHT

Item no.	RLT-100-106S
Manufacturer	ReliaTech
Amount	3ug
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes By Cell Type Peptides & Proteins Recombinant Proteins Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis
Type	Cytokines and Growth Factors
Format	Lyophilized
Specific against	Human (Homo sapiens)
Host	Insect Cells
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Alias	TNFSF14, HVEM-L, LIGHT, tumor necrosis factor (ligand) superfamily, member 14
Available
NCBI Gene ID	8740
Uniprot	O43557
Biological Activity	Determined by its cytotoxic effect on HT-29 cells (human colon adenocarcinoma cells) in the presence of human IFN-gamma.
Description	LIGHT belongs to the TNF family of ligands, and can signal through the herpes virus entry mediator type A receptor (HVEM, TNFRSF14), LTßR, or bind to a decoy receptor, DcR3. It is expressed in splenocytes, activated PBL, CD+8 tumor infiltrating lymphocytes, granulocytes, and monocytes. LIGHT has the ability to active NFkB, to co-stimulate the activation of lymphocytes and to induce apoptosis in certain human tumor cells. Recombinant human LIGHT has a calculated mass of 19.3 kDa containing 177 amino acid residues. Due to glycosylation LIGHT migrates between 20.0-22.5 kDa by SDS-PAGE under non-reducing conditions.
Endotoxin Levels	< 0.1 ng/µg of protein (<1EU/µg)
Length [aa]	177
Molecular Weight	19.3 kDa
mRNA RefSeq	NM_003807.3
Protein RefSeq	NP_003798.2
Protein Sequence	RLGEMVTRLP DGPAGSWEQL IQERRSHEVN PAAHLTGANS SLTGSGGPLL WETQLGLAFL RGLSYHDGAL VVTKAGYYYI YSKVQLGGVG CPLGLASTIT HGLYKRTPRY PEELELLVSQ QSPCGRATSS SRVWWDSSFL GGVVHLEAGE KVVVRVLDER LVRLRDGTRS YFGAFMV
Purity Confirmation	> 95% by SDS-PAGE & HPLC analyses
Synonyms	TNFSF14, HVEM-L, LIGHT; tumor necrosis factor (ligand) superfamily, member 14
Uniprot ID	O43557

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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Amount: 3ug

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Delivery expected until 8/21/2025

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