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IGF-BP1

IGF-BP1

Item no.	RLT-100-197
Manufacturer	ReliaTech
Amount	25ug
Category	Metabolism Diabetes Peptides & Proteins Recombinant Proteins
Type	Cytokines and Growth Factors
Format	Lyophilized
Specific against	Human (Homo sapiens)
Host	E.coli
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Alias	IGFBP1, AFBP, IBP1, PP12, IGF-BP25, hIGFBP-1
Available
NCBI Gene ID	3484
Uniprot	P08833
Biological Activity	The ED50 was determined by its ability to inhibit IGF-I induced proliferation of MCF-7 is = 0.5 µg/ml in the presence of 6 ng/ml of human IGF-I.
Description	IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP1 is a 25.4 kDa cysteine-rich secreted protein expressed in liver, deciduas, and kidneys and is the most abundant IGF-BP in amniotic fluid. Levels of IGF-BP1 in serum are lowest after food. IGF-BP1 binds to both IGF-I and IGF-II with equal affinity. Phosphorylated IGF-BP1 hinders IGF actions, where as nonphosphorylated IGF-BP1 is stimulatory. Recombinant human IGF-BP1 is a 25.4 kDa protein consisting of 235 amino acid residues (Isoform A).
Endotoxin Levels	< 0.1 ng/µg of protein (<1EU/µg)
Length [aa]	235
Molecular Weight	25.4 kDa
mRNA RefSeq	NM_000596.2
Protein RefSeq	NP_000587.1
Protein Sequence	MAPWQCAPCS AEKLALCPPV SASCSEVTRS AGCGCCPMCA LPLGAACGVA TARCARGLSC RALPGEQQPL HALTRGQGAC VQESDASAPH AAEAGSPESP ESTEITEEEL LDNFHLMAPS EEDHSILWDA ISTYDGSKAL HVTNIKKWKE PCRIELYRVV ESLAKAQETS GEEISKFYLP NCNKNGFYHS RQCETSMDGE AGLCWCVYPW NGKRIPGSPE IRGDPNCQIY FN
Purity Confirmation	> 98% by SDS-PAGE & HPLC analyses
Synonyms	IGFBP1; AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1
Uniprot ID	P08833

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 25ug

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Delivery expected until 8/21/2025

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