Comparison

Anti-CCNE1 Antibody European Partner

Item no. STJ113478-50
Manufacturer St John's Laboratory
Amount 50 ul
Category
Type Antibody
Applications WB, IHC
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Rabbit
Isotype IgG
Conjugate/Tag Unconjugated
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias CCNE1 antibody, G1/S-specific cyclin-E1 antibody, CCNE1 antibody, CCNE antibody
Available
Storage Conditions
Store at -20C. Avoid freeze / thaw cycles.
Molecular Weight
47.077 kDa
Description
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB.
Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification
Affinity purification
Immunogen
Recombinant protein of human CCNE1
Tissue specificity
Highly expressed in testis and placenta, Low levels in bronchial epithelial cells
Clonality
Polyclonal
Gene symbol
CCNE1
Dilution range
WB1:500 - 1:2000
IHC1:50 - 1:100
Note
For Research Use Only (RUO).
Short Description
Rabbit polyclonal to CCNE1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

 
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