« Back
Home /
Anti-CYP3A4 antibody

Anti-CYP3A4 antibody

Manufacturer	St John's Laboratory
Category	Oncology Food Safety Drugs Antibodies By Cell Type Carcinoma Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Polyclonal
Specific against	Human, Mouse, Rat
Isotype	IgG
Applications	WB, IHC
Amount	50ul
Host	Rabbit
Item no.	STJ115444-50
eClass 6.1	32160702
eClass 9.0	32160702
Available
Clonality	Polyclonal
Conjugation	Unconjugated
Formulation	PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification	Affinity purification
Uniprot ID	P08684
Storage	Store at-20° C and avoid freeze-thaw cycles.
Description	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21. 1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID	1576
Gene symbol	CYP3A4
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 244-503 of human CYP3A4 (NP_059488. 2).
Short Description	Rabbit polyclonal against CYP3A4
Tissue specificity	Expressed in prostate and liver. According to some authors, it is not expressed in brain. According to others, weak levels of expression are measured in some brain locations. Also expressed in epithelium of the small intestine and large intestine, bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia, gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the ovary (at protein level).
Cellular localization	Endoplasmic Reticulum Membrane Single-Pass Membrane Protein Microsome Membrane
Molecular weight	Calculated: 57kDa. Observed: 57kDa
Dilution range	WB 1:500-1:2000 IHC 1:50-1:200
Alternative names	Anti-Cytochrome P450 3a4 antibody Anti-1-4-Cineole 2-Exo-Monooxygenase antibody Anti-1-8-Cineole 2-Exo-Monooxygenase antibody Anti-Albendazole Monooxygenase antibody Anti-Sulfoxide-Forming antibody Anti-Albendazole Sulfoxidase antibody Anti-Cypiiia3 antibody Anti-Cypiiia4 antibody Anti-Cholesterol 25-Hydroxylase antibody Anti-Cytochrome P450 3a3 antibody Anti-Cytochrome P450 Hlp antibody Anti-Cytochrome P450 Nf-25 antibody Anti-Cytochrome P450-Pcn1 antibody Anti-Nifedipine Oxidase antibody Anti-Quinine 3-Monooxygenase antibody Anti-CYP3A4 CYP3A3 antibody
Protein name	Cytochrome P450 3a4 1-4-Cineole 2-Exo-Monooxygenase 1-8-Cineole 2-Exo-Monooxygenase Albendazole Monooxygenase Sulfoxide-Forming Albendazole Sulfoxidase Cypiiia3 Cypiiia4 Cholesterol 25-Hydroxylase Cytochrome P450 3a3 Cytochrome P450 Hlp Cytochrome P450 Nf-25 Cytochrome P450-Pcn1 Nifedipine Oxidase Quinine 3-Monooxygenase
Note	FOR RESEARCH USE ONLY (RUO).
Swiss port key	CP3A4_HUMAN

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 50ul

available

Delivery expected until 6/6/2024