Anti-CASP8 antibody (290-370)

Store at-20°C, and avoid repeat freeze-thaw cycles.

Caspase-8 is a protein encoded by the CASP8 gene which is approximately 55, 3 kDa. Caspase-8 is localised to the cytoplasm and is involved in the TNFR1 pathway, dimerization of procaspase-8, activated TLR4 signalling, apoptosis signalling and toll-like receptor signalling pathways. This protein falls under the cysteine-aspartic acid protease family. It pays a role in the programmed cell death induced by Fas and various apoptotic stimuli. Caspase-8 isoform 1, 5 and 7 are expressed in a wide variety of tissues. Mutations in the CASP8 gene may result in a caspase-8 deficiency. STJ92025 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Caspase-8 protein.

1 mg/ml

290-370 aa

Cytoplasm

Caspase-8
Casp-8
Apoptotic Cysteine Protease
Apoptotic Protease Mch-5
Cap4
Fadd-Homologous Ice/Ced-3-Like Protease
Fadd-Like Ice
Flice
Ice-Like Apoptotic Protease 5
Mort1-Associated Ced-3 Homolog
Mach [Cleaved Into-Caspase-8 Subunit P18-Caspase-8 Subunit P10]

IF 1:50-200
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000

290-370 aa