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Anti-CDKN1B antibody [5B4-E6-E11-A8]

Anti-CDKN1B antibody [5B4-E6-E11-A8]

Item no.	STJ99255-50
Manufacturer	St John's Laboratory
Amount	50 ug
Category	Oncology Neuroscience Neural Lineage Markers Antibodies By Cell Type Blastoma Carcinoma Hematology Lymphoma Melanoma Sarcoma Cell Biology Cell Status Apoptosis Western Blot Senescence Proliferation Primary Antibodies By Organ Lung Cancer Bladder Cancer
Type	Antibody Monoclonal
Format	Liquid
Applications	WB
Clone	5B4-E6-E11-A8
Specific against	Mouse (Murine, Mus musculus)
Host	Mouse
Isotype	IgG1
Conjugate/Tag	Unconjugated
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, p27Kip1
Similar products	Cyclin-dependent kinase inhibitor 1B Cyclin-dependent kinase inhibitor p27 p27Kip1
Available
Storage Conditions	Store at-20°C, and avoid repeat freeze-thaw cycles.
Molecular Weight	27kDa
Description	Mouse monoclonal to p27 KIP1.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen	Purified recombinant human p27 Kip1 protein fragments expressed in E.coli.
Tissue specificity	Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.
Cellular localization	Nucleus. Cytoplasm. Endosome. Nuclear and cytoplasmic in quiescent cells. AKT-or RSK-mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6. this leads to lysosomal degradation.
Clonality	Monoclonal
Protein name	Cyclin-dependent kinase inhibitor 1B Cyclin-dependent kinase inhibitor p27 p27Kip1
Gene symbol	CDKN1B
Dilution range	WB 1:1000
Note	For Research Use Only (RUO).
Short Description	Mouse monoclonal against p27 KIP1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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