Anti-c-FOS antibody

Store at-20°C, and avoid repeated freeze-thaw cycles.

c-FOS is a member of the FOS transcription factor family which forms dimers with c-JUN to produce the Activator Protein 1 (AP-1) complex which plays a key role in critical cellular processes such as cell proliferation, differentiation and apoptosis (Chiu et al., 1988). c-FOS expression has been demonstrated to be a useful marker of neuronal activation as it is rapidly induced following various stimuli (Hoffman et al., 1993). Additionally, c-FOS has been shown to be overexpressed in a variety of malignant tumor types (Milde-Langosch 2005).

This antibody was protein g purified culture from supernatant.

Nucleus
Endoplasmic Reticulum
Cytoplasm
Cytosol
In Quiescent Cells
Present In Very Small Amounts In The Cytosol
Following Induction Of Cell Growth
First Localizes To The Endoplasmic Reticulum And Only Later To The Nucleus
Localization At The Endoplasmic Reticulum Requires Dephosphorylation At Tyr-10 And Tyr-30

Proto-Oncogene C-Fos
Cellular Oncogene Fos
G0/G1 Switch Regulatory Protein 7

For Research Use Only (RUO).