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Pyrimethamine

Pyrimethamine

Item no.	TMO-T0849-500mg
Manufacturer	TargetMol
CASRN	58-14-0
Amount	500 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 200 mg 25 mg 2 mg 500 mg 50 mg
Category	Food Safety Vitamines Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Citations	1. Rastelli G, et al. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3257-60.
Smiles	C(C)C=1C(=C(N)N=C(N)N1)C2=CC=C(Cl)C=C2
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Pirimecidan,RP 4753,Pirimetamin
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Parasite\|\|\|DHFR\|\|\|Antifolate
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	248.71
Description	Pyrimethamine (Pirimecidan) is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug.
Pathways	Microbiology/Virology\|\|\|Cell Cycle/Checkpoint\|\|\|Metabolism\|\|\|DNA Damage/DNA Repair
Bioactivity	Pyrimethamine is a dihydrofolate reductase(DHFR) inhibitor with an IC50 of 15.4 nM. It is a medication used for protozoal infections. It is commonly used as an antimalarial drug (for both treatment and prevention of malaria), and is also used (combined with sulfadiazine) in the treatment of Toxoplasma gondii infections in immune-compromised patients, such as HIV-positive individuals. It interferes with folic acid synthesis by inhibiting the enzyme dihydrofolate reductase (DHFR). Folic acid is needed for DNA and RNA synthesis in many species, including protozoa.
Receptor	DHFR

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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