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Dasatinib monohydrate

Dasatinib monohydrate

Item no.	TMO-T1448L-100mg
Manufacturer	TargetMol
CASRN	863127-77-9
Amount	100 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 200 mg 25 mg 500 mg 50 mg
Category	Oncology Reagents & Chemicals Molecules By Organ Heart & Blood Cancer
Type	Molecules
Specific against	other
Purity	0,98
Smiles	n1cc(sc1Nc1nc(nc(N2CCN(CC2)CCO)c1)C)C(=O)Nc1c(cccc1C)Cl.O
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	BMS-354825 Monohydrate
Similar products	863127-77-9
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Src\|\|\|c-Kit\|\|\|Apoptosis\|\|\|Bcr-Abl\|\|\|Autophagy\|\|\|Ephrin Receptor
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	506.03
Description	Dasatinib monohydrate (BMS-354825 Monohydrate) is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib monohydrate binds to and inhibits the growth-promoting activities of these kinases. Apparently, because of its less stringent binding affinity for the BCR-ABL kinase, Dasatinib monohydrate has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations.
Pathways	Angiogenesis\|\|\|Apoptosis\|\|\|Cytoskeletal Signaling\|\|\|Tyrosine Kinase/Adaptors\|\|\|Autophagy

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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