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Nilotinib

Nilotinib

Item no.	TMO-T1524-500mg
Manufacturer	TargetMol
CASRN	641571-10-0
Amount	500 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 1 mL 200 mg 25 mg 500 mg 50 mg 5 mg
Category	Oncology Reagents & Chemicals Molecules By Organ Heart & Blood Cancer
Type	Molecules
Specific against	other
Citations	1. Maekawa T, et al. Int J Clin Oncol. 2007 Oct;12(5):327-40.
Smiles	C(F)(F)(F)C=1C=C(C=C(NC(=O)C2=CC(NC=3N=C(C=CN3)C=4C=CC=NC4)=C(C)C=C2)C1)N5C=NC(C)=C5
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Tasigna,AMN107
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Autophagy\|\|\|Bcr-Abl
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	529.52
Description	Nilotinib (AMN107) is a Bcr-Abl tyrosine kinase inhibitor with oral activity. Nilotinib has antitumor activity and may be used for the treatment of Imatinib-resistant chronic myelogenous leukemia (CML).
Pathways	Cytoskeletal Signaling\|\|\|Tyrosine Kinase/Adaptors\|\|\|Angiogenesis\|\|\|Autophagy
Bioactivity	Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). In June 2006, a Phase I clinical trial found nilotinib has a relatively favorable safety profile and shows activity in cases of CML resistant to treatment with imatinib (Gleevec?), another tyrosine kinase inhibitor currently used as a first-line treatment.
Receptor	Bcr-Abl

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