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Palbociclib

Palbociclib

Item no.	TMO-T1785-500mg
Manufacturer	TargetMol
CASRN	571190-30-2
Amount	500 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 200 mg 500 mg 50 mg 5 mg
Category	Neuroscience Molecular Targets for Neuroscience Neural Signaling Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Citations	1. Fry DW, et al. Mol Y Ther, 2004, 3(11), 1427-1438.
Smiles	O=C1N(C=2C(C(C)=C1C(C)=O)=CN=C(NC3=CC=C(C=N3)N4CCNCC4)N2)C5CCCC5
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	PD 0332991
Shipping Condition	Cool pack
Available
Manufacturer - Targets	CDK
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	447.53
Description	Palbociclib (PD 0332991) is a CDK inhibitor that inhibits CDK4 and CDK6 (IC50=11/16 nM) and is orally active. Palbociclib has anti-tumorigenic activity and has investigational potential for use in ER-positive and HER2-negative breast cancer.
Pathways	Cell Cycle/Checkpoint
Bioactivity	Palbociclib (PD-0332991) is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.
Receptor	CDK4; CDK6

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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