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Y-27632

Y-27632

Item no.	TMO-T1870-25mg
Manufacturer	TargetMol
CASRN	146986-50-7
Amount	25 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 200 mg 25 mg 2 mg 500 mg 50 mg 5 mg
Category	Oncology Reagents & Chemicals Molecules By Organ Lung Cancer
Type	Molecules
Specific against	other
Citations	1. Isler D, et al. Pharmacol Rep. 2014, 66(1), 114-120.
Smiles	C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	ROCK inhibitor
Shipping Condition	Cool pack
Available
Manufacturer - Targets	ROCK\|\|\|Apoptosis
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	247.34
Description	Y-27632 is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells.
Pathways	Stem Cells\|\|\|Cell Cycle/Checkpoint\|\|\|Cytoskeletal Signaling\|\|\|Apoptosis
Bioactivity	Y-27632 is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM in a cell-free assay, exhibits >200-fold selectivity over Others kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.
Receptor	ROCK1; ROCK2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 25 mg

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