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Vistusertib

Vistusertib

Item no.	TMO-T1961-200mg
Manufacturer	TargetMol
CASRN	1009298-59-2
Amount	200 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mg 1 mL 200 mg 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Citations	1. Sylvie M. Guichard, et al. Y Research: April 15, 2012; Volume 72, Issue 8, Supplement 1.
Smiles	CNC(=O)c1cccc(c1)-c1ccc2c(nc(nc2n1)N1CCOC[C@@H]1C)N1CCOC[C@@H]1C
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	AZD2014
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Apoptosis\|\|\|Autophagy\|\|\|mTOR\|\|\|S6 Kinase\|\|\|PI3K\|\|\|Akt
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	462.54
Description	Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.
Pathways	Cytoskeletal Signaling\|\|\|PI3K/Akt/mTOR signaling\|\|\|Autophagy\|\|\|MAPK\|\|\|Apoptosis
Bioactivity	AZD2014 is a novel mTOR inhibitor with IC50 of 2.8 nM in a cell-free assay; highly selective against multiple PI3K isoforms (alpha/beta/gamma/delta). Phase 2.
Receptor	P-Akt (S473); mTOR; PI3Kalpha; pS6 (S235/236)

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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