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LY2109761

LY2109761

Item no.	TMO-T2123-1mg
Manufacturer	TargetMol
CASRN	700874-71-1
Amount	1 mg
Quantity options	100 mg 1 mL x 10 mM (in DMSO) 10 mg 1 mL 1 mg 200 mg 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Molecules
Specific against	other
Purity	0,9983
Citations	1. Melisi D, et al. Mol Y Ther, 2008, 7(4), 829-840.
Smiles	C(CN1CCOCC1)Oc1ccc2c(ccnc2c1)-c1c2CCCn2nc1-c1ccccn1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	TGF-beta/Smad inhibitor
Shipping Condition	Cool pack
Available
Manufacturer - Targets	TGF-beta/Smad\|\|\|Autophagy
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	441.52
Description	LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively; shown to negatively affect the phosphorylation of Smad2.
Pathways	Autophagy\|\|\|Stem Cells
Bioactivity	LY2109761, a new-type, specific TGF-beta receptor type I/II (TbetaRI/II) dual inhibitor( Ki=38 nM and 300 nM), exhibits to negatively affect the phosphorylation of Smad2.
Receptor	TbetaRI; TbetaRII

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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